Sativex and Marinol have both been examined in treatment of central neuropathic pain in MS, with comparable results . However, adverse events were comparable or greater with Marinol than with Sativex employing THC dosages some 2.5 times higher due to the presence of accompanying CBD (Russo 2006b; Russo and Guy 2006). In a study of spinal injury pain, NRS of pain were not statistically different from placebo, probably due to the short duration of the trial, but secondary endpoints were clearly positive . Finally, in an RCT of intractable lower urinary tract symptoms in MS, accompanying pain in affected patients was prominently alleviated .
In contrast, neither THC nor CBD produce significant COX inhibition at normal dosage levels . While there have been no head-to-head comparative RCTs of Sativex with other cannabinoid agents, certain contrasts can be drawn.
Detects even trace amounts of chemical pesticides in hemp concentrates using advanced testing procedures. Our CBD oil is third-party tested for potency and quality, and we make public the results of every single test to our clients. Our stringent independent lab-testing program ensures that you get the very best, and most potent, CBD oil available.
- Cannabidiol, or CBD, is a chemical compound in marijuana with a variety of uses.
- When heat is applied, THC, an addictive compound, breaks down and creates a mind-altering high by binding with the cannabinoid receptors in the brain; raw cannabis doesn’t do this.
- The cannabis plant has hundreds of active chemicals, including more than 120 cannabinoids found in the stalks, seeds and flowers.
- Depending on the amount of THC, it can induce relaxation and enjoyable CBD oil altered perceptions in some people, and anxiety, increased blood pressure, hallucinations, paranoia and even psychosis in others.
Cannabis flavonoids in whole cannabis extracts may also contribute useful activity . Apigenin inhibits TNF-α , a mechanism germane to multiple sclerosis and rheumatoid arthritis. Cannflavin A, a flavone unique to cannabis, inhibits PGE-2 thirty times more potently than aspirin , but has not been subsequently investigated. The anti-inflammatory contributions of THC are also extensive, including inhibition of PGE-2 synthesis , decreased platelet aggregation , and stimulation of lipooxygenase .
It is likely that lower serum levels of Sativex in therapeutic usage, in conjunction with anti-psychotic properties of CBD , would minimize risks. Children and adolescents have been excluded from Sativex RCTs to date. SAFEX studies of Sativex have yielded few incidents of thought disorder, paranoia or related complaints. No known abuse or diversion incidents have been reported with Sativex to date . Sativex is expected to be placed in Schedule IV of the Misuse of Drugs Act in the United Kingdom once approved.
In a Phase II double-blind, randomized, placebo-controlled, 5-week study of 56 rheumatoid arthritis patients with Sativex , employed nocturnal treatment only to a maximum of 6 sprays per evening (16.2 mg THC + 15 mg CBD). In the final treatment week, morning pain on movement, morning pain at rest, DAS-28 measure of disease activity, and SF-MPQ pain at present all favored Sativex over placebo . In a controlled double-blind RCT of central neuropathic pain, 66 MS subjects showed mean Numerical Rating Scale analgesia favoring Sativex over placebo . Finally, β-sitosterol, a phytosterol found in cannabis, reduced topical inflammation 65% and chronic edema 41% in skin models .
How Should I Take Cbd?
Detects trace amounts of heavy metals to ensure the safest product possible. Determines if there are any microorganisms and harmful pathogens such as bacteria and fungi present in the hemp.
Lack of analgesic efficacy of oral delta-9-tetrahydrocannabinol in postoperative pain. Review of the validity and significance of cannabis withdrawal syndrome. Berlach DM, Shir Y, Ware MA. Experience with the synthetic cannabinoid nabilone in chronic noncancer pain. Debate continues with regard to the relationship between cannabis usage and schizophrenia (reviewed ). An etiological relationship is not supported by epidemiological data , but if present, should bear relation to dose and length of high exposure.